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Target
Nuclear receptor ROR-gamma
Ligand
BDBM536333
Substrate
n/a
Meas. Tech.
Gal4 Ligand Binding Assay
IC50
<50±n/a nM
Citation
 Mohan, R; Nuss, J; Harris, J; Yuan, S Spirocyclic ROR-gamma modulators US Patent  US11242350 Publication Date 2/8/2022 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM536333
Synonyms:
6-((4'-(1,1,1,3,3,3-hexafluoro-2- hydroxypropan-2-yl)-2-isopropyl-2'- methyl-[1,1'-biphenyl]-4-yl)methyl)- 2-thia-6-azaspiro[3.4]octane 2,2- dioxide | US11242350, Example 11
Type:
Small organic molecule
Emp. Form.:
C26H29F6NO3S
Mol. Mass.:
549.569
SMILES:
CC(C)c1cc(CN2CCC3(CS(=O)(=O)C3)C2)ccc1-c1ccc(cc1C)C(O)(C(F)(F)F)C(F)(F)F
Structure:
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