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Target
Kelch-like ECH-associated protein 1 [321-609]
Ligand
BDBM50180851
Substrate
n/a
Meas. Tech.
Nrf2-Keap1 FP Assay #1
IC50
550±n/a nM
Citation
 Davies, TG; Woolford, AJ; Willems, HM; Norton, D; Heightman, TD; Kerns, JK Nrf2 regulators US Patent  US10144731 Publication Date 12/4/2018 
Target
Name:
Kelch-like ECH-associated protein 1 [321-609]
Synonyms:
INRF2 | KEAP1 | KEAP1_HUMAN | KIAA0132 | KLHL19 | Keap1 (aa 321-609)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
31620.58
Organism:
Homo sapiens (Human)
Description:
Q14145[321-609]
Residue:
289
Sequence:
APKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
  
Inhibitor
Name:
BDBM50180851
Synonyms:
CHEMBL3818085 | US10144731, Example 54
Type:
Small organic molecule
Emp. Form.:
C24H23ClN4O4S
Mol. Mass.:
498.982
SMILES:
CN(Cc1cc(ccc1Cl)[C@H](CC(O)=O)c1ccc2n(C)nnc2c1)S(=O)(=O)c1ccccc1 |r|
Structure:
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