BindingDB PrimarySearch_ki

Found 3271 with Last Name = 'woolford' and Initial = 'aj'

Platelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)

IC50: 0.0350nMAssay Description:Inhibition of Lp-PLA2 in whole human plasma pre-incubated for 15 mins before 2-thio-PAF substrate additionMore data for this Ligand-Target Pair

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3D Structure (crystal)

Platelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)

IC50: 0.0490nMAssay Description:Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrateMore data for this Ligand-Target Pair

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3D Structure (crystal)

Platelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)

IC50: 0.0490nMAssay Description:Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Platelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)

IC50: 0.0490nMAssay Description:Inhibition of recombinant human Lp-PLA2 incubated for 20 mins by Thio-PAF assayMore data for this Ligand-Target Pair

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3D Structure (crystal)

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50573875(CHEMBL4869086)

IC50: 1.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details Article PubMed

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418177(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.10nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418177(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418177(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.10nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

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Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418281((2R)-2-[6-(5-chloro-2-{[(2S)-1- hydroxypropan-2-yl...)

IC50: 1.20nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

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Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418281((2R)-2-[6-(5-chloro-2-{[(2S)-1- hydroxypropan-2-yl...)

IC50: 1.20nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM417954(US10457669, Example 615)

IC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418188(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM417999(US10457669, Example 675 | US11001575, Example 675)

IC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM417999(US10457669, Example 675 | US11001575, Example 675)

IC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM417999(US10457669, Example 675 | US11001575, Example 675)

IC50: 1.30nMAssay Description:Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details Article PubMed

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM417953(US10457669, Example 614 | US11001575, Example 616)

IC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418188(2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.30nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418230((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418230((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418223((2R)-2-(3-{5-chloro-2-[(2-methyl-2H- 1,2,3-triazol...)

IC50: 1.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Platelet-activating factor acetylhydrolase(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50182422(CHEMBL3818650)

IC50: 1.40nMAssay Description:Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418223((2R)-2-(3-{5-chloro-2-[(2-methyl-2H- 1,2,3-triazol...)

IC50: 1.40nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418307((2R)-2-(6-}5-chloro-2-[(oxetan-3- yl)amino]pyrimid...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418305((2R)-2-(6-{5-chloro-2-[(2- methylpyrimidin-4-yl)am...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418192(2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1-o...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418305((2R)-2-(6-{5-chloro-2-[(2- methylpyrimidin-4-yl)am...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418266((2R)-2-(6-{5-chloro-2-[(1-methyl-1H- 1,2,3-triazol...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418229((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418192(2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1-o...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418266((2R)-2-(6-{5-chloro-2-[(1-methyl-1H- 1,2,3-triazol...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418229((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418307((2R)-2-(6-}5-chloro-2-[(oxetan-3- yl)amino]pyrimid...)

IC50: 1.5nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418308((2R)-2-[6-(5-chloro-2-{[cis-3- methoxycyclobutyl]a...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418300((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418300((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418298((2R)-2-(6-{5-chloro-2-[(2- methylpyrimidin-4-yl)am...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418133((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418200((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418276((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418200((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418133((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM497509(2-(6-{5-chloro-2-[(oxan- 4-yl)amino]pyrimidin-4- y...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418298((2R)-2-(6-{5-chloro-2-[(2- methylpyrimidin-4-yl)am...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418308((2R)-2-[6-(5-chloro-2-{[cis-3- methoxycyclobutyl]a...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM417711(2-(6-{5-bromo-2- [(oxan-4- yl)amino]pyrimidiin-4- ...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418276((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM417812(US10457669, Example 450)

IC50: 1.60nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418192(2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1-o...)

IC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418089((2R)-2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl...)

IC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Mitogen-activated protein kinase 1(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM418105((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...)

IC50: 1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details US Patent

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Targets 21▿
- Mitogen-activated protein kinase 1 1887
- Nuclear factor erythroid 2-related factor 2 285
- E3 ubiquitin-protein ligase XIAP 269
- Kelch-like ECH-associated protein 1 [321-609] 269
- Baculoviral IAP repeat-containing protein 2 215
- NAD(P)H dehydrogenase [quinone] 1 87
- Platelet-activating factor acetylhydrolase 76
- Kelch-like ECH-associated protein 1 61
- Cyclin-A2/Cyclin-dependent kinase 2 30
- Heat shock protein HSP 90-alpha/90-beta 29
- Cyclin-dependent kinase 4 20
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 13
- Histone deacetylase 2 12
- Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 6
- Cytochrome P450 3A4 4
- Mitogen-activated protein kinase 1/3 3
- cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A 1
- Solute carrier organic anion transporter family member 1B1 1
- Aurora kinase A 1
- Cyclin-dependent kinase 5 activator 1 1
- Bile salt export pump 1
- ...
Publications 19▿
- US Patent US10457669 (2019) 927
- US Patent US11001575 (2021) 923
- US Patent US10144731 (2018) 519
- US Patent US9018214 (2015) 370
- US Patent US9155743 (2015) 90
- US Patent US10272095 (2019) 87
- J Med Chem 59: 10738-10749 (2016) 55
- J Med Chem 64: 15949-15972 (2021) 50
- J Med Chem 51: 4986-99 (2008) 39
- J Med Chem 62: 4683-4702 (2019) 33
- J Med Chem 53: 5942-55 (2010) 29
- J Med Chem 59: 5356-67 (2016) 25
- J Med Chem 58: 6574-88 (2015) 24
- J Med Chem 61: 4978-4992 (2018) 22
- US Patent US8598217 (2013) 20
- J Med Chem 64: 12286-12303 (2021) 18
- J Med Chem 59: 3991-4006 (2016) 16
- ACS Med Chem Lett 3: 445-449 (2012) 12
- ACS Med Chem Lett 13: 1591-1597 (2022) 12
Institutions 6▿
- Otsuka Pharmaceutical 1850
- Glaxosmithkline 606
- Astex Therapeutics 509
- Astex Pharmaceuticals 255
- Astex 39
- TBA 12
Affinity: 0.035 to 3.4E+6 nM▿
- IC50 2857
- Kd 38
- EC50 374
- Affinity ≤ nM
Xtal structures: 82
Docked structures: 28
Catalog Cmpds: 42