Reaction Details Report a problem with these data
Target
WD repeat-containing protein 5
Ligand
BDBM552989
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Assay
Kd
0.300±n/a nM
Citation
 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A; Prakesch, M; Stille, JK Substituted carboxamides as inhibitors of WDR5 protein-protein binding US Patent  US11319299 Publication Date 5/3/2022 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM552989
Synonyms:
N-[5-[6- (cyclopropylmethoxy) pyridin-3-yl]-4-fluoro-2- [(3S,5R)-3,4,5- trimethylpiperazin-1- yl]phenyl]-6-oxo-4- (trifluoromethyl)-1H- pyridine-3-carboxamide | US11319299, Example 39
Type:
Small organic molecule
Emp. Form.:
C29H31F4N5O3
Mol. Mass.:
573.5818
SMILES:
C[C@H]1CN(C[C@@H](C)N1C)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(OCC2CC2)nc1 |r|
Structure:
Search PDB for entries with ligand similarity: