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Target
WD repeat-containing protein 5
Ligand
BDBM552991
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Assay
Kd
8.60±n/a nM
Citation
 Al-Awar, R; Zepeda-Velazquez, CA; Poda, G; Isaac, M; Uehling, D; Wilson, B; Joseph, B; Liu, Y; Subramanian, P; Mamai, A; Prakesch, M; Stille, JK Substituted carboxamides as inhibitors of WDR5 protein-protein binding US Patent  US11319299 Publication Date 5/3/2022 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM552991
Synonyms:
N-[4-fluoro-2-(4- methylpiperazin-1-yl)-5- [6-(morpholin-4- ylmethyl)pyridin-3- yl]phenyl]-6-oxo-4- (trifluoromethyl)-1H- pyridine-3-carboxamide | US11319299, Example 41
Type:
Small organic molecule
Emp. Form.:
C28H30F4N6O3
Mol. Mass.:
574.5698
SMILES:
CN1CCN(CC1)c1cc(F)c(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(CN2CCOCC2)nc1
Structure:
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