Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM138357
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Binding Assay
IC50
277±n/a nM
Citation
 Graef, IA; Alhamadsheh, MM Identification of stabilizers of multimeric proteins US Patent  US11337935 Publication Date 5/24/2022 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM138357
Synonyms:
US10278929, Compound 6 | US11337935, Compound 6 | US8877795, 6
Type:
Small organic molecule
Emp. Form.:
C11H9F3N4O2S
Mol. Mass.:
318.275
SMILES:
COc1ccc(\C=N\n2c(S)nnc2C(F)(F)F)cc1O
Structure:
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