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Target
MAP kinase-activated protein kinase 3
Ligand
BDBM558866
Substrate
n/a
Meas. Tech.
ADP-Glo Kinase Activity Assay
IC50
4100±n/a nM
Citation
 Scheidt, KA; Schiltz, GE; Clutter, MR; Kwong, AJ 3-arylindazoles as selective MEK4 inhibitors US Patent  US11370770 Publication Date 6/28/2022 
Target
Name:
MAP kinase-activated protein kinase 3
Synonyms:
3pK | Chromosome 3p kinase | MAP kinase-activated protein kinase 3 (MAPKAP-K3) | MAPK-Activated Protein Kinase 3 (MK3) | MAPK-activated protein kinase 3 | MAPK3_HUMAN | MAPKAP kinase 3 | MAPKAPK-3 | MAPKAPK3
Type:
Serine/threonine-protein kinase
Mol. Mass.:
42991.57
Organism:
Homo sapiens (Human)
Description:
Recombinant MAPKAPK3 was phosphorylated by incubation with active p38alpha before assays.
Residue:
382
Sequence:
MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSASQGCNNQ
  
Inhibitor
Name:
BDBM558866
Synonyms:
US11370770, Compound 6r
Type:
Small organic molecule
Emp. Form.:
C15H13N3O
Mol. Mass.:
251.2832
SMILES:
Cc1ccc2[nH]nc(-c3ccc(cc3)C(N)=O)c2c1
Structure:
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