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Target
Cyclin-A2/Cyclin-dependent kinase 2
Ligand
BDBM572073
Substrate
n/a
Meas. Tech.
Protein Kinase Assay Condition A (Thiol Containing Conditions)
IC50
<100±n/a nM
Citation
 Kanouni, T; Arnold, L; Kaldor, SW; Murphy, EA Inhibitors of cyclin-dependent kinases US Patent  US11447493 Publication Date 9/20/2022 
Target
Name:
Cyclin-A2/Cyclin-dependent kinase 2
Synonyms:
CDK2/Cyclin A
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1655488
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
Cyclin-A2
Synonyms:
CCNA2 | CCNA2_BOVIN | Cyclin-A | Cyclin-A2
Type:
PROTEIN
Mol. Mass.:
48258.58
Organism:
Bos taurus
Description:
ChEMBL_117723
Residue:
430
Sequence:
MLGSSAHGPAAREAGSAVTLQQTAFQEDQENVNPEKAAPAQQPRTRAGLAVLRAGNSRGPAPQRPKTRRVAPLKDLPINDEYVPVPPWKANNKQPAFTIHVDEAEEEIQKRPTESKKSESEDVLAFNSAVTLPGPRKPLAPLDYPMDGSFESPHTMEMSVVLEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIREKYKNSKYHGVSLLNPPETLNV
  
Inhibitor
Name:
BDBM572073
Synonyms:
(R)-2-((1-(4- acrylamidobenzoyl)pyrrolidin-3- yl)amino)quinazoline-7-carboxylic acid | US11447493, Example 38
Type:
Small organic molecule
Emp. Form.:
C23H21N5O4
Mol. Mass.:
431.4439
SMILES:
OC(=O)c1ccc2cnc(N[C@@H]3CCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)nc2c1 |r|
Structure:
Search PDB for entries with ligand similarity: