Reaction Details Report a problem with these data
Target
Transmembrane anterior posterior transformation protein 1 homolog
Ligand
BDBM575106
Substrate
n/a
Meas. Tech.
Assessing Antiviral Activity Against Human Cytomegalovirus (HCMV)
IC50
317±n/a nM
Citation
 Remiszewski, S; Chiang, LW; Murphy, EA; Sun, Q; Kayser, F; Fink, SJ Broad spectrum antiviral compositions and methods US Patent  US11459321 Publication Date 10/4/2022 
Target
Name:
Transmembrane anterior posterior transformation protein 1 homolog
Synonyms:
CMVFR | Cytomegalovirus partial fusion receptor | TAPT1 | TAPT1_HUMAN
Type:
Protein
Mol. Mass.:
64270.48
Organism:
Human
Description:
Q6NXT6
Residue:
567
Sequence:
MAGVGDAAAPGEGGGGGVDGPQRDGRGEAEQPGGSGGQGPPPAPQLTETLGFYESDRRRERRRGRTELSLLRFLSAELTRGYFLEHNEAKYTERRERVYTCLRIPRELEKLMVFGIFLCLDAFLYVFTLLPLRVFLALFRLLTLPCYGLRDRRLLQPAQVCDILKGVILVICYFMMHYVDYSMMYHLIRGQSVIKLYIIYNMLEVADRLFSSFGQDILDALYWTATEPKERKRAHIGVIPHFFMAVLYVFLHAILIMVQATTLNVAFNSHNKSLLTIMMSNNFVEIKGSVFKKFEKNNLFQMSNSDIKERFTNYVLLLIVCLRNMEQFSWNPDHLWVLFPDVCMVIASEIAVDIVKHAFITKFNDITADVYSEYRASLAFDLVSSRQKNAYTDYSDSVARRMGFIPLPLAVLLIRVVTSSIKVQGILSYACVILFYFGLISLKVLNSIVLLGKSCQYVKEAKMEEKLSNPPATCTPGKPSSKSQNKCKPSQGLSTEENLSASITKQPIHQKENIIPLLVTSNSDQFLTTPDGDEKDITQDNSELKHRSSKKDLLEIDRFTICGNRID
  
Inhibitor
Name:
BDBM575106
Synonyms:
US11459321, Example 56
Type:
Small organic molecule
Emp. Form.:
C27H27N5O2S
Mol. Mass.:
485.601
SMILES:
Cc1cn(c(C)n1)-c1ccc2CCN(Cc2c1)c1ncc(Cc2ccc(cc2)N2CCOC2=O)s1
Structure:
Search PDB for entries with ligand similarity: