Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM504512
Substrate
n/a
Meas. Tech.
In Vitro DGAT2 Assay and Determination of IC50 Values for DGAT2 Inhibitors
IC50
200±n/a nM
Citation
 Edmonds, DJ; Filipski, KJ; Futatsugi, K; Garnsey, MR; Lee, JC; Smaltz, DJ Diacylglycerol acyl transferase 2 inhibitor US Patent  US11471458 Publication Date 10/18/2022 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM504512
Synonyms:
US11065249, Example 25 | US11471458, Example 25 | rac-2-{5-[(3-ethoxypyridin-2- yl)oxy]pyridin-3-yl}-N-[(3R,5S)-5- fluoropiperidin-3-yl]pyrimidine-5- carboxamide, trifluoroacetate salt
Type:
Small organic molecule
Emp. Form.:
C22H23FN6O3
Mol. Mass.:
438.4548
SMILES:
CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CNC[C@@H](F)C1 |r,$;;;;;;;;;;;;;;;;;;;;;;;;;;;N;;;;$|
Structure:
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