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Target
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
Ligand
BDBM585834
Substrate
n/a
Meas. Tech.
Cbl-b Displacement Assay (Cbl-b Inhibition Assay low)
IC50
<1±n/a nM
Citation
 Sands, AT; Bence, NF; Zapf, CW; Cohen, F; Wang, C; Cummins, T; Tanaka, H; Shunatona, H; Cardozo, M; Weiss, D; Gosling, J Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof US Patent  US11530229 Publication Date 12/20/2022 
Target
Name:
Isoform Truncated 1 of E3 ubiquitin-protein ligase CBL-B [36-427]
Synonyms:
E3 ubiquitin-protein ligase CBL-B [36-427] | CBLB_HUMAN | CBLB | RNF56
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45487.32
Organism:
Human
Description:
aa 36-427 (sequence in paper SEQ ID No: 1)
Residue:
392
Sequence:
PKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD
  
Inhibitor
Name:
BDBM585834
Synonyms:
US11530229, Compound 49
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cn1cnnc1C[C@]1(c2cccc(N3Cc4c(cc(CN5CCC[C@H](C(F)(F)F)C5)nc4C4CC4)C3=O)c2)C[C@H](C#N)C1
Structure:
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