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Target
Histone deacetylase 1
Ligand
BDBM592435
Substrate
n/a
Meas. Tech.
Inhibition of Histone Deacetylase Enzymatic Activity Assay
IC50
555±n/a nM
Citation
 Holson, E; Wagner, FF; Weiwer, M; Tsai, L; Haggarty, SJ; Zhang, Y Inhibitors of histone deacetylase US Patent  US11572368 Publication Date 2/7/2023 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM592435
Synonyms:
US11572368, Compound 116
Type:
Small organic molecule
Emp. Form.:
C16H19N3OS
Mol. Mass.:
301.407
SMILES:
Cc1csc(c1)-c1ccc(N)c(NC(=O)N2CCCC2)c1
Structure:
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