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Target
Histone deacetylase 2
Ligand
BDBM592458
Substrate
n/a
Meas. Tech.
Inhibition of Histone Deacetylase Enzymatic Activity Assay
IC50
3050±n/a nM
Citation
 Holson, E; Wagner, FF; Weiwer, M; Tsai, L; Haggarty, SJ; Zhang, Y Inhibitors of histone deacetylase US Patent  US11572368 Publication Date 2/7/2023 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM592458
Synonyms:
US11572368, Compound 132
Type:
Small organic molecule
Emp. Form.:
C18H24N4O2
Mol. Mass.:
328.4088
SMILES:
CC(=O)N1CCN(CC1)C(=O)Nc1cc(ccc1N)C1=CCCC1 |t:21|
Structure:
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