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Target
Rho-associated protein kinase 1 [1-535]
Ligand
BDBM598571
Substrate
n/a
Meas. Tech.
Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay)
IC50
6.00±n/a nM
Citation
 Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent  US11613531 Publication Date 3/28/2023 
Target
Name:
Rho-associated protein kinase 1 [1-535]
Synonyms:
ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1)
Type:
Enzyme
Mol. Mass.:
62220.48
Organism:
Homo sapiens (Human)
Description:
aa 1-535
Residue:
535
Sequence:
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
  
Inhibitor
Name:
BDBM598571
Synonyms:
N-(2-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluoropyrimidin-4-yl)-1H-indazol-5-amine | US11613531, Example 217
Type:
Small organic molecule
Emp. Form.:
C17H18FN7
Mol. Mass.:
339.3701
SMILES:
Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CC2CCC(C1)N2
Structure:
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