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Target
Rho-associated protein kinase 1 [1-535]
Ligand
BDBM598585
Substrate
n/a
Meas. Tech.
Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay)
IC50
42.0±n/a nM
Citation
 Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent  US11613531 Publication Date 3/28/2023 
Target
Name:
Rho-associated protein kinase 1 [1-535]
Synonyms:
ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1)
Type:
Enzyme
Mol. Mass.:
62220.48
Organism:
Homo sapiens (Human)
Description:
aa 1-535
Residue:
535
Sequence:
MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
  
Inhibitor
Name:
BDBM598585
Synonyms:
N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5,6-dimethylpyrimidin-4-yl)-1H-indazol-5-amine | US11613531, Example 29
Type:
Small organic molecule
Emp. Form.:
C19H23N7
Mol. Mass.:
349.4328
SMILES:
Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)N1C2CCC1CNC2
Structure:
Search PDB for entries with ligand similarity: