Reaction Details Report a problem with these data
Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM611803
Substrate
n/a
Meas. Tech.
ADP-Glo Kinase Assay
IC50
17.4±n/a nM
Citation
 Lewis, RT; Hamilton, M; Ray, WJ; Alvarez, F; Reyna, N; Cross, J; Ramaswamy, SK Inhibitors of receptor interacting protein kinase I for the treatment of disease US Patent  US11718612 Publication Date 8/8/2023 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM611803
Synonyms:
3-Bromo-6-(3- chloro-2-fluoro- phenyl)-2-(2,5- difluorobenzyl)- 2,4,5,6-tetrahydro- 7H-pyrazolo[3,4-c]- pyridin-7-one | US11718612, Example 101
Type:
Small organic molecule
Emp. Form.:
C19H12BrClF3N3O
Mol. Mass.:
470.67
SMILES:
Fc1ccc(F)c(Cn2nc3c(CCN(C3=O)c3cccc(Cl)c3F)c2Br)c1
Structure:
Search PDB for entries with ligand similarity: