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Target
Transcriptional enhancer factor TEF-4/Isoform 5 of Transcriptional coactivator [50-100]
Ligand
BDBM626323
Substrate
n/a
Meas. Tech.
HTRF Assay
EC50
>50000±n/a nM
Citation
 Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent  US11787775 Publication Date 10/17/2023 
Target
Name:
Transcriptional enhancer factor TEF-4/Isoform 5 of Transcriptional coactivator [50-100]
Synonyms:
TEAD2 YAP50-100 combined
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Transcriptional enhancer factor TEF-4
Synonyms:
TEA domain family member 2 | TEAD-2 | TEAD2 | TEAD2_HUMAN | TEF4 | Transcriptional enhancer factor TEF-4
Type:
PROTEIN
Mol. Mass.:
49241.42
Organism:
Homo sapiens
Description:
ChEMBL_119051
Residue:
447
Sequence:
MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD
  
Component 2
Name:
Isoform 5 of Transcriptional coactivator [50-100]
Synonyms:
Transcriptional coactivator YAP1 (50-100) | YAP1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5701.47
Organism:
Homo sapiens (Human)
Description:
P46937-5[50-100]
Residue:
51
Sequence:
AGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPE
  
Inhibitor
Name:
BDBM626323
Synonyms:
US11787775, Compound 8 | methyl 2-[[[4-cyano-7-(4- isopropylphenyl)-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoate
Type:
Small organic molecule
Emp. Form.:
C23H24N2O3
Mol. Mass.:
376.4483
SMILES:
COC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)C(C)C
Structure:
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