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Target
Monoglyceride lipase
Ligand
BDBM631283
Substrate
n/a
Meas. Tech.
MAGL Inhibitory Activity Assay
IC50
3.00±n/a nM
Citation
 Bell, C; Benz, J; Gobbi, L; Grether, U; Groebke Zbinden, K; Hornsperger, B; Kocer, B; Kroll, C; Kuhn, B; Lutz, MD; O''Hara, F; Richter, H; Ritter, M; Rombach, D; Kuratli, M Heterocyclic compounds as monoacylglycerol lipase inhibitors US Patent  US11802133 Publication Date 10/31/2023 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM631283
Synonyms:
US11802133, Example 220
Type:
Small organic molecule
Emp. Form.:
C22H26F3N3O4
Mol. Mass.:
453.4547
SMILES:
CC(=O)c1cc(ccc1CCC1CN(C1)C(=O)N1CC[C@@H]2OCC(=O)N[C@@H]2C1)C(F)(F)F |r|
Structure:
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