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Target
Protein-lysine 6-oxidase
Ligand
BDBM633250
Substrate
n/a
Meas. Tech.
Inhibition of LOX and LOXL1-4
IC50
>300±n/a nM
Citation
 Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Schilter Sambade, H; Zhou, W; Perryman, LA BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF US Patent  US20230349907 Publication Date 11/2/2023 
Target
Name:
Protein-lysine 6-oxidase
Synonyms:
1.4.3.13 | LOX | LYOX_BOVIN | Lysyl oxidase | Protein-lysine 6-oxidase | Protein-lysine 6-oxidase, long form | Protein-lysine 6-oxidase, short form
Type:
PROTEIN
Mol. Mass.:
47015.72
Organism:
Bos taurus
Description:
ChEMBL_118967
Residue:
417
Sequence:
MRFAWTALLGSLQLCALVRCAPPAASHRQPPREQAAAPGAWRQKIQWENNGQVFSLLSLGSQYQPQRRRDPGATAPGAANATAPQMRTPILLLRNNRTAAARVRTAGPSAAAAGRPRPAARHWFQAGYSTSGAHDAGTSRADNQTAPGEVPTLSNLRPPNRVEVDGMVGDDPYNPYKYTDDNPYYNYYDTYERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMAMYNLRCAAEENCLASSAYRDVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY
  
Inhibitor
Name:
BDBM633250
Synonyms:
N-((1-(4-(((1-((Z)-4-amino-2-fluorobut-2-en-1-yl)-1H-1,2,3-triazol-4-yl)(4-(N,N-dimethylsulfamoyl)phenyl)methoxy)methyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)-1-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide hydrochloride | US20230349907, Compound 1-16
Type:
Small organic molecule
Emp. Form.:
C46H65FN12O10S2
Mol. Mass.:
1029.211
SMILES:
CN(C)S(=O)(=O)c1ccc(cc1)C(OCc1ccc(cc1)-n1cc(CNC(=O)CCOCCOCCOCCOCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)nn1)c1cn(C\C(F)=C\CN)nn1 |r,w:13.13|
Structure:
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