Reaction Details Report a problem with these data
Target
Caspase-7
Ligand
BDBM10215
Substrate
Caspase-3 (7) Fluorogenic Substrate
Meas. Tech.
Enzyme Inhibition Assay
Ki
6200±n/a nM
Citation
 Fattorusso, R; Jung, D; Crowell, KJ; Forino, M; Pellecchia, M Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach. J Med Chem 48:1649-56 (2005) [PubMed]  Article 
Target
Name:
Caspase-7
Synonyms:
Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase
Type:
Enzyme
Mol. Mass.:
34273.91
Organism:
Homo sapiens (Human)
Description:
P55210
Residue:
303
Sequence:
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ
  
Inhibitor
Name:
BDBM10215
Synonyms:
2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4-[3-(trifluoromethyl)phenyl]-1,3-thiazole | BI-9B12 | Burnham Institute Compound 1
Type:
Small organic molecule
Emp. Form.:
C18H12F3NO2S
Mol. Mass.:
363.354
SMILES:
FC(F)(F)c1cccc(c1)-c1csc(n1)C1COc2ccccc2O1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-3 (7) Fluorogenic Substrate
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
1477.75
Organism:
n/a
Description:
AFC = 7-Amino-4-trifluoromethylcoumarin
Residue:
16
Sequence:
ACASPGLVALASPAFC