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Target
Caspase-4
Ligand
BDBM10305
Substrate
Caspase-4 Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
Ki
>25000±n/a nM
Citation
 Lee, D; Long, SA; Murray, JH; Adams, JL; Nuttall, ME; Nadeau, DP; Kikly, K; Winkler, JD; Sung, CM; Ryan, MD; Levy, MA; Keller, PM; DeWolf, WE Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem 44:2015-26 (2001) [PubMed]  Article 
Target
Name:
Caspase-4
Synonyms:
CASP-4 | CASP4 | CASP4_HUMAN | Caspase 4 | Caspase-4 subunit 1 | Caspase-4 subunit 2 | ICE(rel)-II | ICH-2 protease | ICH2 | TX protease
Type:
Enzyme
Mol. Mass.:
43257.75
Organism:
Homo sapiens (Human)
Description:
P49662
Residue:
377
Sequence:
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
  
Inhibitor
Name:
BDBM10305
Synonyms:
(S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isatin | 5-{[(2S)-2-(methoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione | CHEMBL60190 | Isatin Sulfonamide 16
Type:
Small organic molecule
Emp. Form.:
C14H16N2O5S
Mol. Mass.:
324.352
SMILES:
COC[C@@H]1CCCN1S(=O)(=O)c1ccc2NC(=O)C(=O)c2c1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Caspase-4 Fluorogenic Substrate
Synonyms:
Ac-LEED-AMC
Type:
n/a
Mol. Mass.:
1334.60
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
14
Sequence:
ACLEGLGLASPAMC