Reaction Details
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Target
Caspase-8
Ligand
BDBM10323
Substrate
Caspase-8 Fluorogenic Substrate
Meas. Tech.
Caspase Inhibition Assay
Ki
>5000±n/a nM
Citation

More Info.:
Target
Name:
Caspase-8
Synonyms:
Caspase | Caspase-8 subunit p18 | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CASP-8 | Caspase-8 subunit p10 | MACH | FADD-homologous ICE/CED-3-like protease | FLICE | ICE-like apoptotic protease 5 | CAP4 | MORT1-associated CED-3 homolog | FADD-like ICE | CASP8_HUMAN | CASP8 | MCH5
Type:
Enzyme
Mol. Mass.:
55373.89
Organism:
Human
Description:
Q14790
Residue:
479
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Inhibitor
Name:
BDBM10323
Synonyms:
JMC522188 Compound 2 | IST-3 | CHEMBL439753 | 1-benzyl-5-{[(2S)-2-(phenoxymethyl)pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione | Pyrrolidine Isatin Analogue 2 | (S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl}isatin | Isatin Sulfonamide 34
Type:
Small organic molecule
Emp. Form.:
C26H24N2O5S
Mol. Mass.:
476.55
SMILES:
O=C1C(=O)N(Cc2ccccc2)c2ccc(S(=O)(=O)N3CCC[C@H]3COc3ccccc3)cc21
Substrate
Name:
Caspase-8 Fluorogenic Substrate
Synonyms:
Ac-IETD-AMC
Type:
Peptide
Mol. Mass.:
1673.49
Organism:
n/a
Description:
AMC=7-Amino-4-methylcoumarin
Residue:
16
Sequence:
ACILEGLTHRASPAMC