Reaction Details Report a problem with these data
Target
Eukaryotic initiation factor 4A-III
Ligand
BDBM65493
Substrate
n/a
Meas. Tech.
ATPase enzyme assay
IC50
1.1e+2±n/a nM
Citation
 Iwatani-Yoshihara, M; Ito, M; Ishibashi, Y; Oki, H; Tanaka, T; Morishita, D; Ito, T; Kimura, H; Imaeda, Y; Aparicio, S; Nakanishi, A; Kawamoto, T Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol 12:1760-1768 (2017) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-III
Synonyms:
ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DDX48 | DEAD box protein 48 | EIF4A3 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | IF4A3_HUMAN | KIAA0111 | NMP 265 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | hNMP 265
Type:
Protein
Mol. Mass.:
46871.02
Organism:
Homo sapiens (Human)
Description:
P38919
Residue:
411
Sequence:
MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
  
Inhibitor
Name:
BDBM65493
Synonyms:
eIF4A3 inhibitor, 2
Type:
Small organic molecule
Emp. Form.:
C25H19Br2ClN4O2
Mol. Mass.:
602.705
SMILES:
Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 |r|
Structure:
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