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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM322382
Substrate
n/a
Meas. Tech.
Human alpha7 nAChR Binding Assay
Ki
180±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent  US10183938 Publication Date 1/22/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM322382
Synonyms:
(R)-N-(2,2-dimethylquinuclidin-3-yl)-8,9-dihydro-7H-thieno[2,3-f]chromene-2-carboxamide | US10183938, Compound (R)-145
Type:
Small organic molecule
Emp. Form.:
C21H26N2O2S
Mol. Mass.:
370.508
SMILES:
CC1(C)[C@H](NC(=O)c2cc3ccc4OCCCc4c3s2)C2CCN1CC2 |wU:3.3,(1.21,2.94,;2.54,3.71,;1.21,4.48,;3.31,2.37,;2.54,1.04,;1,1.04,;.23,2.37,;.23,-.29,;.86,-1.7,;-.29,-2.73,;-.29,-4.27,;-1.62,-5.04,;-2.95,-4.27,;-4.29,-5.04,;-5.62,-4.27,;-5.62,-2.73,;-4.29,-1.96,;-2.95,-2.73,;-1.62,-1.96,;-1.3,-.45,;4.85,2.37,;4.92,3.52,;4.34,4.53,;3.31,5.04,;4.85,5.04,;5.62,3.71,)|
Structure:
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