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Target
Mitogen-activated protein kinase 1 [8-360]
Ligand
BDBM193401
Substrate
n/a
Meas. Tech.
ERK-2 Enzymatic Assay
pH
7.3±n/a
IC50
171±n/a nM
Comments
extracted
Citation
 Blake, JF; Cook, A; Gaudino, J; Gunawardana, IW; Hicken, EJ; Hunt, KW; Lyon, M; Metcalf, AT; Mohr, PJ; Moreno, DA; Newhouse, B; Ren, L; Schwarz, J; Chen, H; Gazzard, L; Schmidt, J; Do, S Serine/threonine kinase inhibitors US Patent  US9670208 Publication Date 6/6/2017 
Target
Name:
Mitogen-activated protein kinase 1 [8-360]
Synonyms:
ERK2 | Human ERK-2 | MAPK1 | MK01_HUMAN | Mitogen Activated Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (aa 8-360) | PRKM1 | PRKM2
Type:
n/a
Mol. Mass.:
40835.09
Organism:
Homo sapiens (Human)
Description:
P28482 aa 8-360
Residue:
353
Sequence:
GAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM193401
Synonyms:
US9670208, Example 136 1-methyl-4-phenyl-5-(7-(2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)pyrrolidin-2-one
Type:
Small organic molecule
Emp. Form.:
C26H27N7O2
Mol. Mass.:
469.5383
SMILES:
CN1C(C(CC1=O)c1ccccc1)c1nnc2cc(ccn12)-c1ccnc(NC2CCOCC2)n1
Structure:
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