Reaction Details Report a problem with these data
Target
E3 ubiquitin-protein ligase XIAP [241-356]
Ligand
BDBM13185
Substrate
Smac-based peptide
Meas. Tech.
Ligand Binding Assay
pH
7.4±n/a
Temperature
295.15±n/a K
Kd
2000±n/a nM
Citation
 Park, CM; Sun, C; Olejniczak, ET; Wilson, AE; Meadows, RP; Betz, SF; Elmore, SW; Fesik, SW Non-peptidic small molecule inhibitors of XIAP. Bioorg Med Chem Lett 15:771-5 (2005) [PubMed]  Article 
Target
Name:
E3 ubiquitin-protein ligase XIAP [241-356]
Synonyms:
API3 | BIR3 domain of X-linked inhibitor of apoptosis protein | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR3) | E3 ubiquitin-protein ligase XIAP BIR-3 | E3 ubiquitin-protein ligase XIAP BIR3 | IAP3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP | XIAP-BIR3 | XIAP_HUMAN | baculovirus IAP repeat 3 (BIR3) domain of XIAP
Type:
Protein Binding Domain
Mol. Mass.:
13276.62
Organism:
Homo sapiens (Human)
Description:
BIR3 of XIAP: RESIDUES 241-356.
Residue:
116
Sequence:
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
  
Inhibitor
Name:
BDBM13185
Synonyms:
(2S)-2-amino-N-{5-methyl-4-[(2,4,6-trimethylphenyl)methyl]-1H-imidazol-2-yl}propanamide | SMAC mimetic compound 12
Type:
Small organic molecule
Emp. Form.:
C17H24N4O
Mol. Mass.:
300.3987
SMILES:
C[C@H](N)C(=O)Nc1nc(C)c(Cc2c(C)cc(C)cc2C)[nH]1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Smac-based peptide
Synonyms:
6-Carboxyfluorescein (FAM) labeled peptide AVPIAQK
Type:
Peptide
Mol. Mass.:
1328.08
Organism:
n/a
Description:
n/a
Residue:
12
Sequence:
AVPIAQKFAMNH