Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM337680
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
222±n/a nM
Citation
 Fürstner, C; Ackerstaff, J; Straub, A; Meier, H; Tinel, H; Zimmermann, K; Tersteegen, A; Zubov, D; Kast, R; Schamberger, J; Schäfer, M Substituted uracils and use thereof US Patent  US9751843 Publication Date 9/5/2017 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM337680
Synonyms:
3-[3-Fluoro-2-(trifluoromethyl)benzyl]-2,4-dioxo-1-[4-(2-oxotetrahydropyrimidin-1(2H)-yl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid | US9751843, 55
Type:
Small organic molecule
Emp. Form.:
C23H18F4N4O5
Mol. Mass.:
506.4064
SMILES:
OC(=O)c1cn(-c2ccc(cc2)N2CCCNC2=O)c(=O)n(Cc2cccc(F)c2C(F)(F)F)c1=O
Structure:
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