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Target
Methionine aminopeptidase
Ligand
BDBM17863
Substrate
Met-Gly-Met-Met
Meas. Tech.
EcMAP Enzyme Inhibition Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
1700±n/a nM
Citation
 Evdokimov, AG; Pokross, M; Walter, RL; Mekel, M; Barnett, BL; Amburgey, J; Seibel, WL; Soper, SJ; Djung, JF; Fairweather, N; Diven, C; Rastogi, V; Grinius, L; Klanke, C; Siehnel, R; Twinem, T; Andrews, R; Curnow, A Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. Proteins 66:538-46 (2007) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM17863
Synonyms:
Amino-Alcohol Inhibitor, 12 | methyl 2-[(2S)-2-[(2S,3R)-3-amino-2-hydroxy-3-[4-(trifluoromethyl)phenyl]propanamido]propanamido]acetate
Type:
Small organic molecule
Emp. Form.:
C16H20F3N3O5
Mol. Mass.:
391.3423
SMILES:
COC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)c1ccc(cc1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Met-Gly-Met-Met
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
468.65
Organism:
n/a
Description:
n/a
Residue:
4
Sequence:
MGMM