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Target
Kappa-type opioid receptor
Ligand
BDBM364559
Substrate
n/a
Meas. Tech.
kappa-Opioid Receptor Binding Assay
Ki
0.057±0.01 nM
Citation
 Youngman, M Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans US Patent  US9862726 Publication Date 1/9/2018 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM364559
Synonyms:
4-Chloro-N-((4bR,6S,8aS,9R)-11- (cyclopropylmethyl)-3-methoxy- 5,6,7,8,9,10-hexahydro-9,4b- (epiminoethano)-8a,6- (epoxymethano)phenanthren-6-yl)- benzenesulfonamide | US9862726, Compound 24
Type:
Small organic molecule
Emp. Form.:
C28H33ClN2O4S
Mol. Mass.:
529.091
SMILES:
COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC5(CC[C@@]34OC5)NS(=O)(=O)c3ccc(Cl)cc3)c2c1 |r,THB:9:8:20:34.5.6|
Structure:
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