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Target
Kappa-type opioid receptor
Ligand
BDBM364563
Substrate
n/a
Meas. Tech.
kappa-Opioid Receptor Binding Assay
Ki
3348±325.0 nM
Citation
 Youngman, M Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans US Patent  US9862726 Publication Date 1/9/2018 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM364563
Synonyms:
(4bR,6S,8aS,9S)-11-(cyclopropylmethyl)-6- hydroxy-3-methoxy-5,6,7,8-tetrahydro- 9,4b-(epiminoethano)-8a,6- (epoxymethano)phenanthrene-10,15(9H)- dione | US9862726, Compound 33
Type:
Small organic molecule
Emp. Form.:
C22H25NO5
Mol. Mass.:
383.4376
SMILES:
COc1ccc2C(=O)[C@H]3N(CC4CC4)CC[C@@]4(C[C@@]5(O)CC[C@@]34OC5=O)c2c1 |r,TLB:10:9:22:26.5.6,THB:25:24:21.20:17.16|
Structure:
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