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Target
Signal transducer and activator of transcription 3
Ligand
BDBM20276
Substrate
c-fos sis inducible element (hSIE)
Meas. Tech.
Electrophoretic Mobility Shift Assay (EMSA)
pH
7.8±n/a
Temperature
295.15±n/a K
IC50
605000±87000 nM
Citation
 Gunning, PT; Katt, WP; Glenn, M; Siddiquee, K; Kim, JS; Jove, R; Sebti, SM; Turkson, J; Hamilton, AD Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. Bioorg Med Chem Lett 17:1875-8 (2007) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
Acute-phase response factor | Aprf | STAT3 alpha | STAT3_MOUSE | Signal transducer and activator of transcription 3 | Stat3 | Transcription Factor STAT3
Type:
Cytosolic Transcription Factor
Mol. Mass.:
88050.28
Organism:
Mus musculus (mouse)
Description:
Bacterially expressed protein was used in the FP assay.
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
  
Inhibitor
Name:
BDBM20276
Synonyms:
4-[(2S)-2-[(4-cyanophenyl)formamido]-2-{[(1S)-1-(cyclohexylcarbamoyl)-3-methylbutyl]carbamoyl}ethyl]phenoxyphosphonic acid | ISS836
Type:
Small organic molecule
Emp. Form.:
C29H37N4O7P
Mol. Mass.:
584.6004
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)NC1CCCCC1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
c-fos sis inducible element (hSIE)
Synonyms:
32P-labeled c-fos sis inducible element (hSIE)
Type:
Oligonucleotide
Mol. Mass.:
2192.56
Organism:
n/a
Description:
hSIE derived from the c-fos gene promoter.
Residue:
24
Sequence:
AGCTTCATTTCCCGTAAATCCCTA