Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Hemagglutinin
Ligand
BDBM247025
Substrate
n/a
Meas. Tech.
Endonuclease Assay
pH
7.5±n/a
IC50
13200±n/a nM
Comments
extracted
Citation
Lavoie, EJ; Bauman, JD; Sagong, HY; Arnold, E; Parhi, A; Das, K; Vijayan, SK; Patel, D Therapeutic hydroxyquinolones US Patent US9701638 Publication Date 7/11/2017 More Info.:
Target
Name:
Hemagglutinin
Synonyms:
HA | Hemagglutinin HA1 chain
Type:
Enzyme Catalytic Domain
Mol. Mass.:
63281.44
Organism:
Influenza A virus (strain swl A/California/04/2009 H1N1)
Description:
C3W5S1
Residue:
566
Sequence:
MKAILVVLLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETPSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADTYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNIPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGTYDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASSLVLVVSLGAISFWMCSNGSLQCRICI
Inhibitor
Name:
BDBM247025
Synonyms:
US9701638, 16
Type:
Small organic molecule
Emp. Form.:
C16H12FNO2
Mol. Mass.:
269.2704
SMILES:
Cc1c(O)c(=O)[nH]c2cc(ccc12)-c1ccc(F)cc1
Structure:
