Reaction Details Report a problem with these data
Target
Mitotic checkpoint serine/threonine-protein kinase BUB1
Ligand
BDBM367507
Substrate
n/a
Meas. Tech.
Bub1 kinase assay
IC50
5.00±n/a nM
Citation
 Graham, K; Klar, U; Briem, H; Siemeister, G; Mönning, U; Balint, J 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones US Patent  US10227299 Publication Date 3/12/2019 
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1
Synonyms:
BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1
Type:
PROTEIN
Mol. Mass.:
122372.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510603
Residue:
1085
Sequence:
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASAVLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGNNMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKEKLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKLHQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPPVVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSGAEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTLPDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGLPQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDFTSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEKSPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
  
Inhibitor
Name:
BDBM367507
Synonyms:
(6RS)-2-2-[(4-Fluorobenzoyl)amino]pyridin-4-yl-N,N-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-6-carboxamide | US10227299, Example 195
Type:
Small organic molecule
Emp. Form.:
C29H26FN5O3
Mol. Mass.:
511.5468
SMILES:
CN(C)C(=O)C1Cc2[nH]c(c(Nc3ccccc3)c2C(=O)C1)-c1ccnc(NC(=O)c2ccc(F)cc2)c1 |w:5.4|
Structure:
Search PDB for entries with ligand similarity: