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Found 2249 with Last Name = 'graham' and Initial = 'k'
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17759((2S)-2-(phosphonomethyl)pentanedioic acid | (S)-2-...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497267((2,6-dimethylpyridin-4- yl)(4-(7-((1R,4S)-4- hydro...)
Affinity DataKi:  0.190nMAssay Description:ATP competitive inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411736(CHEMBL271225)
Affinity DataKi:  0.280nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50055499(CHEMBL3326002)
Affinity DataKi:  0.330nMAssay Description:Inhibition of Mer (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM17659((R,S)-2-phosphonomethylpentanedioic acid | 2-(phos...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataKi:  0.430nMAssay Description:Inhibition of MERTK (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384584(CHEMBL2036807 | US9744172, Compound UNC607A)
Affinity DataKi:  0.560nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384583(CHEMBL2036806)
Affinity DataKi:  0.730nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411731(CHEMBL257726)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286715((S)-3-biphenyl-4-yl-2-((S)-2-mercapto-3-phenyl-pro...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411730(CHEMBL257270)
Affinity DataKi:  1.20nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50286724((S)-3-Biphenyl-4-yl-2-((R)-2-mercapto-3-phenyl-pro...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411736(CHEMBL271225)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411731(CHEMBL257726)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384582(CHEMBL2036805)
Affinity DataKi:  1.40nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398811(CHEMBL2177507)
Affinity DataKi:  1.40nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411733(CHEMBL269997)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411605(CHEMBL252391)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411729(CHEMBL269996)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411737(CHEMBL404117)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411730(CHEMBL257270)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384585(CHEMBL2036809)
Affinity DataKi:  2nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411728(CHEMBL257229)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411729(CHEMBL269996)
Affinity DataKi:  2.40nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411725(CHEMBL271223)
Affinity DataKi:  2.60nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398808(CHEMBL2177506)
Affinity DataKi:  2.60nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411735(CHEMBL402987)
Affinity DataKi:  2.60nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384581(CHEMBL2036804)
Affinity DataKi:  2.70nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50398810(CHEMBL2177509)
Affinity DataKi:  3.10nMAssay Description:Inhibition of NAALADase activity in human LNCaP cell membranes assessed as inhibition of [3H]NAG conversion to [3H]glutamate after 30 mins by liquid ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411736(CHEMBL271225)
Affinity DataKi:  3.20nMAssay Description:Inhibition of human recombinant ACE by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataKi:  3.90nMAssay Description:Inhibition of TYRO3 (unknown origin) using 5'-FAM-EFPIYDFLPAKKK-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50384576(CHEMBL2036808)
Affinity DataKi:  4.30nMAssay Description:Inhibition of Mer using EFPIYDFLPAKKK-CONH2 as substrate by Michaelis-Menton equationMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304731((S)-2-(3-((S)-1-Carboxy-2-(furan-2-yl)ethyl)ureido...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304722((S)-2-(3-((S)-1-Carboxybut-3-ynyl)ureido)-6-(4-iod...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411728(CHEMBL257229)
Affinity DataKi:  5.40nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411734(CHEMBL257727)
Affinity DataKi:  6.90nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411725(CHEMBL271223)
Affinity DataKi:  7.10nMAssay Description:Inhibition of human recombinant ACE2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataKi:  8nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411731(CHEMBL257726)
Affinity DataKi:  8.60nMAssay Description:Inhibition of human recombinant ACE by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411730(CHEMBL257270)
Affinity DataKi:  9.30nMAssay Description:Inhibition of human recombinant ACE by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411606(CHEMBL254282)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304751((S)-2-(3-((S)-1-Carboxybut-3-enyl)ureido)-6-(4-iod...)
Affinity DataKi:  11nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411608(CHEMBL400527)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411722(CHEMBL258333)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411733(CHEMBL269997)
Affinity DataKi:  13nMAssay Description:Inhibition of human recombinant NEP by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50411722(CHEMBL258333)
Affinity DataKi:  16nMAssay Description:Inhibition of human recombinant ACE by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Unc Eshelman School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50469353(CHEMBL4283353)
Affinity DataKi:  16nMAssay Description:Inhibition of FLT3 (unknown origin) using 5'-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by MCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Bayer Healthcare

Curated by ChEMBL
LigandPNGBDBM50304735((S)-2-(3-((S)-1-Carboxy-2-(thiazol-4-yl)ethyl)urei...)
Affinity DataKi:  16.1nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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