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Target
Orotidine-5'-phosphate decarboxylase
Ligand
BDBM21335
Substrate
BDBM21336
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5000±n/a
Temperature
310.1500±n/a K
Ki
26000±2 nM
Citation
 Bello, AM; Poduch, E; Liu, Y; Wei, L; Crandall, I; Wang, X; Dyanand, C; Kain, KC; Pai, EF; Kotra, LP Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase. J Med Chem 51:439-48 (2008) [PubMed]  Article 
Target
Name:
Orotidine-5'-phosphate decarboxylase
Synonyms:
ODCase | Orotidine 5-Phosphate Decarboxylase | Orotidine Monophosphate Decarboxylase (ODCase)
Type:
Enzyme
Mol. Mass.:
37826.43
Organism:
malaria parasite P. falciparum
Description:
n/a
Residue:
323
Sequence:
MGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNNIKKNLKEKYINNVSIKKDILLKAPDNIIREEKSEEFFYFFNHFCFYIINETNKYALTFKMNFAFYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIGNTVKNYRKFIFEYLKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVKTTNPDSAIFQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGANSYDEMNYIRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIGRAITKNPYPQKAAQMYYDQINAILKQNMES
  
Inhibitor
Name:
BDBM21335
Synonyms:
JMC521648 Compound 34 | 6-cyanouridine 5-monophosphate | {[(2R,3S,4R,5R)-5-(6-cyano-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid | C6-Uridine Derivative, 6
Type:
Small organic molecule
Emp. Form.:
C10H12N3O9P
Mol. Mass.:
349.03
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(cc(=O)[nH]c1=O)C#N |r|
Structure:
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Substrate
Name:
BDBM21336
Synonyms:
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | orotidine 5-monophosphate | orotidylic acid | OMP
Type:
Nucleoside or nucleotide
Emp. Form.:
C10H13N2O11P
Mol. Mass.:
368.03
SMILES:
C1=C(N(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O)C(=O)O
Structure:
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