Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1 [30-579]
Ligand
BDBM23020
Substrate
BDBM22988
Meas. Tech.
FAAH Inhibition Assay
IC50
1900±n/a nM
Citation
Ortar, G; Cascio, MG; De Petrocellis, L; Morera, E; Rossi, F; Schiano-Moriello, A; Nalli, M; de Novellis, V; Woodward, DF; Maione, S; Di Marzo, V New N-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. J Med Chem 50:6554-69 (2007) [PubMed] Article
More Info.:
Target
Name:
Fatty-acid amide hydrolase 1 [30-579]
Synonyms:
Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:
Single-pass membrane protein; homodimer
Mol. Mass.:
60474.00
Organism:
Rattus norvegicus (rat)
Description:
P97612 (aa 30-579)
Residue:
550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQPS
Inhibitor
Name:
BDBM23020
Synonyms:
3-chlorophenyl N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]carbamate | N-arachidonoylserotonin carbamate analogue, 3k
Type:
Small organic molecule
Emp. Form.:
C17H15ClN2O3
Mol. Mass.:
330.766
SMILES:
Oc1ccc2[nH]cc(CCNC(=O)Oc3cccc(Cl)c3)c2c1
Substrate
Name:
BDBM22988
Synonyms:
(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide | AEA | ANANDAMIDE | Arachidonoyl ethanolamide | Arachidonoyl ethanolamide (AEA) | Arachidonoylethanolamide (AEA) | Arachidonylethanolamide | CHEMBL15848 | [14C]Anandamide | [3H]Anandamide
Type:
radiolabeled substrate
Emp. Form.:
C22H37NO2
Mol. Mass.:
347.5347
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCO