Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase
Ligand
BDBM23226
Substrate
BDBM23230
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
IC50
>225000±n/a nM
Citation
Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed] Article
More Info.:
Target
Name:
L-lactate dehydrogenase
Synonyms:
Malate Dehydrogenase (pfMDH) | Malic dehydrogenase | pfMDH
Type:
Oxidoreductase
Mol. Mass.:
34043.75
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
313
Sequence:
MTKIALIGSGQIGAIVGELCLLENLGDLILYDVVPGIPQGKALDLKHFSTILGVNRNILGTNQIEDIKDADIIVITAGVQRKEGMTREDLIGVNGKIMKSVAESVKLHCSKAFVICVSNPLDIMVNVFHKFSNLPHEKICGMAGILDTSRYCSLIADKLKVSAEDVNAVILGGHGDLMVPLQRYTSVNGVPLSEFVKKNMISQNEIQEIIQKTRNMGAEIIKLAKASAAFAPAAAITKMIKSYLYNENNLFTCAVYLNGHYNCSNLFVGSTAKINNKGAHPVEFPLTKEEQDLYTESIASVQSNTQKAFDLIK
Inhibitor
Name:
BDBM23226
Synonyms:
7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]ethoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 4
Type:
Small organic molecule
Emp. Form.:
C21H17NO10
Mol. Mass.:
443.3604
SMILES:
COc1cc(CCOc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)ccc1NC(=O)C(O)=O