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Target
Malate dehydrogenase, cytoplasmic
Ligand
BDBM23231
Substrate
BDBM23230
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
IC50
13600±n/a nM
Citation
 Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed]  Article 
Target
Name:
Malate dehydrogenase, cytoplasmic
Synonyms:
Cytosolic malate dehydrogenase | MDH1 | MDHC_PIG | Malate Dehydrogenase, cytoplasmic | Malate dehydrogenase cytoplasmic
Type:
Oxidoreductase; homodimer
Mol. Mass.:
36453.77
Organism:
Sus scrofa (pig)
Description:
Porcine heart cytoplasmic fraction.
Residue:
334
Sequence:
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEEIAFKDLDVAILVGSMPRRDGMERKDLLKANVKIFKCQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTSDDVKNVIIWGNHSSTQYPDVNHAKVKLQAKEVGVYEAVKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGIISDGNSYGVPDDLLYSFPVTIKDKTWKIVEGLPINDFSREKMDLTAKELAEEKETAFEFLSSA
  
Inhibitor
Name:
BDBM23231
Synonyms:
7-{2-[3-cyano-4-(formamidoformic acid)phenyl]ethoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 3
Type:
Small organic molecule
Emp. Form.:
C21H14N2O9
Mol. Mass.:
438.3439
SMILES:
OC(=O)C(=O)Nc1ccc(CCOc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)cc1C#N
Structure:
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Substrate
Name:
BDBM23230
Synonyms:
2-Oxosuccinic acid | 2-oxobutanedioic acid | Oxaloacetate | Oxaloacetic acid | keto-Oxaloacetate
Type:
Small organic molecule
Emp. Form.:
C4H4O5
Mol. Mass.:
132.0716
SMILES:
OC(=O)CC(=O)C(O)=O
Structure:
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