Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM23741
Substrate
BDBM23739
Meas. Tech.
Enzymatic Inhibition Assay
pH
8±n/a
Temperature
295.15±n/a K
IC50
48±10 nM
Citation
 Zhou, L; Fang, C; Wei, P; Liu, S; Liu, Y; Lai, L Chemically induced dimerization of human nonpancreatic secretory phospholipase A2 by bis-indole derivatives. J Med Chem 51:3360-6 (2008) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM23741
Synonyms:
2-[1-({2-[3-(2-{[3-(carbamoylmethyl)-5-methoxy-2-methyl-1H-indol-1-yl]methyl}phenoxy)propoxy]phenyl}methyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetamide | Bis-indole Derivative, 3
Type:
Small organic molecule
Emp. Form.:
C41H44N4O6
Mol. Mass.:
688.8113
SMILES:
COc1ccc2n(Cc3ccccc3OCCCOc3ccccc3Cn3c(C)c(CC(N)=O)c4cc(OC)ccc34)c(C)c(CC(N)=O)c2c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23739
Synonyms:
DMPC-DCA Phospholipid Blend | dimyristoylphosphatidylcholine-deoxycholic acid
Type:
n/a
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: