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Target
Bcl-2-like protein 1
Ligand
BDBM25524
Substrate
Bak-BH3 peptide
Meas. Tech.
Fluorescence Polarization Assay
pH
8±n/a
Temperature
295.15±n/a K
IC50
100000±n/a nM
Citation
 Bernardo, PH; Wan, KF; Sivaraman, T; Xu, J; Moore, FK; Hung, AW; Mok, HY; Yu, VC; Chai, CL Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors. J Med Chem 51:6699-710 (2008) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM25524
Synonyms:
17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyclo[11.8.0.0^{2,10}.0^{4,8}.0^{14,19}]henicosa-1(13),2,4(8),9,11,14(19),15,17,20-nonaen-21-ium | CHEMBL13045 | CHEMBL258893 | Chelerytherine | Toddalin | chelerythrine
Type:
Small organic molecule
Emp. Form.:
C21H18NO4
Mol. Mass.:
348.3714
SMILES:
COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Bak-BH3 peptide
Synonyms:
F-BakBH3
Type:
Fluorescein-labeled peptide
Mol. Mass.:
1724.92
Organism:
n/a
Description:
Derived from human apoptosis regulator BAK (residues 72-87).
Residue:
16
Sequence:
GQVGRQLAIIGDDINR