Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM26047
Substrate
BDBM26040
Meas. Tech.
Fluorescence Anisoptrophy Kinase Binding Assay
pH
7.5±n/a
Temperature
295.15±n/a K
Kd
1.4±n/a nM
Citation
 Takle, AK; Bamford, MJ; Davies, S; Davis, RP; Dean, DK; Gaiba, A; Irving, EA; King, FD; Naylor, A; Parr, CA; Ray, AM; Reith, AD; Smith, BB; Staton, PC; Steadman, JG; Stean, TO; Wilson, DM The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett 18:4373-6 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM26047
Synonyms:
4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-N-[2-(morpholin-4-yl)ethyl]-5-(pyridin-4-yl)-1H-imidazole-2-carboxamide | imidazole-based compound, 8
Type:
Small organic molecule
Emp. Form.:
C24H26N6O3
Mol. Mass.:
446.5016
SMILES:
O=NC1CCc2cc(ccc12)-c1[nH]c(nc1-c1ccncc1)C(=O)NCCN1CCOCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM26040
Synonyms:
5-{2-[4-(aminomethyl)phenyl]-5-(pyridin-4-yl)-1H-imidazol-4-yl}-2-chlorophenol | CHEMBL200320 | Rhodamine green labeled 5-{2-[4-(aminomethyl)phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl}-2-chlorophenol | Rhodamine green labeled ligand
Type:
fluorescent ligand
Emp. Form.:
C21H17ClN4O
Mol. Mass.:
376.839
SMILES:
NCc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(Cl)c(O)c1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: