Reaction Details Report a problem with these data
Target
Kynurenine--oxoglutarate transaminase 1
Ligand
BDBM31879
Substrate
BDBM31880
Meas. Tech.
hKAT-I Activity Assay
pH
7.5±n/a
Temperature
311.15±n/a K
IC50
140000±200000 nM
Citation
 Han, Q; Robinson, H; Cai, T; Tagle, DA; Li, J Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K. J Med Chem 52:2786-93 (2009) [PubMed]  Article 
Target
Name:
Kynurenine--oxoglutarate transaminase 1
Synonyms:
CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1
Type:
Aminotransferase; Lyase
Mol. Mass.:
47874.00
Organism:
Homo sapiens (Human)
Description:
Recombinant hKAT-1 was expressed and purified from Sf9 insect cells.
Residue:
422
Sequence:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKVEL
  
Inhibitor
Name:
BDBM31879
Synonyms:
3-indolepropionic acid | Acid, 7
Type:
Small organic molecule
Emp. Form.:
C11H11NO2
Mol. Mass.:
189.2105
SMILES:
OC(=O)CCc1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM31880
Synonyms:
Kynurenine
Type:
Amino Acid
Emp. Form.:
C10H12N2O3
Mol. Mass.:
208.2139
SMILES:
NC(CC(=O)c1ccccc1N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: