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Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM399215
Substrate
n/a
Meas. Tech.
TBD
IC50
>50000±n/a nM
Citation
 Roberts, E; Rosen, H; Urbano, M; Guerrero, MA Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders US Patent  US10323029 Publication Date 6/18/2019 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM399215
Synonyms:
US10323029, Generic formula 52474 IB | US11034691, CYM generic formula 52474 IB
Type:
Small organic molecule
Emp. Form.:
C21H14Cl3N3O
Mol. Mass.:
430.714
SMILES:
Cc1cc(ccc1C#N)C(=O)N[C@@H](c1ccc(Cl)c(Cl)c1)c1ccc(Cl)cn1 |r|
Structure:
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