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Target
Sphingosine 1-phosphate receptor 2
Ligand
BDBM399298
Substrate
n/a
Meas. Tech.
TBD
IC50
35400±n/a nM
Citation
 Roberts, E; Rosen, H; Urbano, M; Guerrero, MA Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders US Patent  US10323029 Publication Date 6/18/2019 
Target
Name:
Sphingosine 1-phosphate receptor 2
Synonyms:
EDG5 | S1P2 | S1PR2 | S1PR2_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-5 | Sphingosine-1-phosphate receptor 2 | ndothelial differentiation G-protein coupled receptor 5
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38883.16
Organism:
Homo sapiens (Human)
Description:
Membranes isolated from S1P2-transfected CHO cells were used in ligand binding assay.
Residue:
353
Sequence:
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
  
Inhibitor
Name:
BDBM399298
Synonyms:
US10323029, Generic formula 52604 IB | US11034691, CYM generic formula 52604 IB
Type:
Small organic molecule
Emp. Form.:
C21H11BrCl2N4O
Mol. Mass.:
486.148
SMILES:
Clc1ccc(cc1Cl)[C@H](NC(=O)c1ccc(C#N)c(c1)C#N)c1ccc(Br)cn1 |r|
Structure:
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