Reaction Details Report a problem with these data
Target
Sortase family protein
Ligand
BDBM33379
Substrate
BDBM33299
Meas. Tech.
Fluorescence Resonance Energy Transfer (FRET) Assay
IC50
760±n/a nM
Citation
 Suree, N; Yi, SW; Thieu, W; Marohn, M; Damoiseaux, R; Chan, A; Jung, ME; Clubb, RT Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem 17:7174-85 (2009) [PubMed]  Article 
Target
Name:
Sortase family protein
Synonyms:
Sortase | Sortase A (SrtA)
Type:
Enzyme
Mol. Mass.:
23546.15
Organism:
Staphylococcus aureus
Description:
n/a
Residue:
206
Sequence:
MKKWTNRLMTIAGVVLILVAAYLFAKPHIDNYLHDKDKDEKIEQYDKNVKEQASKDKKQQAKPQIPKDKSKVAGYIEIPDADIKEPVYPGPATPEQLNRGVSFAEENESLDDQNISIAGHTFIDRPNYQFTNLKAAKKGSMVYFKVGNETRKYKMTSIRDVKPTDVGVLDEQKGKDKQLTLITCDDYNEKTGVWEKRKIFVATEVK
  
Inhibitor
Name:
BDBM33379
Synonyms:
pyrazolethione, 3-17
Type:
Small organic molecule
Emp. Form.:
C16H14N4S
Mol. Mass.:
294.374
SMILES:
Cc1[nH]n(-c2ccccc2)c(=S)c1C=Nc1ccccn1 |w:13.14|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM33299
Synonyms:
Abz-LPETG-Dap(Dnp) | o-aminobenzoyl (Abz)-LPETG-diaminopropionic acid-dinitrophenyl- NH2
Type:
internally quenched fluorescent substrate
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
n/a
Structure: