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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM401030
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
700±n/a nM
Citation
 Deshaies, RJ; Li, J; Cohen, S; Perez, C; Ma, Y Inhibitors of RPN11 US Patent  US10005735 Publication Date 6/26/2018 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM401030
Synonyms:
US10005735, Compound 28
Type:
Small organic molecule
Emp. Form.:
C18H17N3O3S2
Mol. Mass.:
387.476
SMILES:
CCOC(=O)c1csc(CCNC(=O)c2cnc3c(S)cccc3c2)n1
Structure:
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