Reaction Details Report a problem with these data
Target
Tubulin--tyrosine ligase
Ligand
BDBM18129
Substrate
n/a
Meas. Tech.
[3H]-Tyr Incorporation Assay
pH
6.8±0
Temperature
310.15±0 K
Ki
25000±0.0 nM
Citation
 Banerjee, A; Panosian, TD; Mukherjee, K; Ravindra, R; Gal, S; Sackett, DL; Bane, S Site-specific orthogonal labeling of the carboxy terminus of alpha-tubulin. ACS Chem Biol 5:777-85 (2010) [PubMed]  Article 
Target
Name:
Tubulin--tyrosine ligase
Synonyms:
TTL | TTL_HUMAN
Type:
PROTEIN
Mol. Mass.:
43213.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_519880
Residue:
377
Sequence:
MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPISNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDVEQPQTQPAAFIKL
  
Inhibitor
Name:
BDBM18129
Synonyms:
(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L-[U-14C]Tyr | Tyrosine | US11021454, Compound L-tyr
Type:
Amino Acid
Emp. Form.:
C9H11NO3
Mol. Mass.:
181.1885
SMILES:
N[C@@H](Cc1ccc(O)cc1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: