Reaction Details Report a problem with these data
Target
Tubulin--tyrosine ligase
Ligand
BDBM36557
Substrate
n/a
Meas. Tech.
[3H]-Tyr Incorporation Assay
pH
6.8±0
Temperature
310.15±0 K
Ki
300000±0.0 nM
Citation
 Banerjee, A; Panosian, TD; Mukherjee, K; Ravindra, R; Gal, S; Sackett, DL; Bane, S Site-specific orthogonal labeling of the carboxy terminus of alpha-tubulin. ACS Chem Biol 5:777-85 (2010) [PubMed]  Article 
Target
Name:
Tubulin--tyrosine ligase
Synonyms:
TTL | TTL_HUMAN
Type:
PROTEIN
Mol. Mass.:
43213.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_519880
Residue:
377
Sequence:
MYTFVVRDENSSVYAEVSRLLLATGHWKRLRRDNPRFNLMLGERNRLPFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELAESCTWFPESYVIYPTNLKTPVAPAQNGIQPPISNSRTDEREFFLASYNRKKEDGEGNVWIAKSSAGAKGEGILISSEASELLDFIDNQGQVHVIQKYLEHPLLLEPGHRKFDIRSWVLVDHQYNIYLYREGVLRTASEPYHVDNFQDKTCHLTNHCIQKEYSKNYGKYEEGNEMFFKEFNQYLTSALNITLESSILLQIKHIIRNCLLSVEPAISTKHLPYQSFQLFGFDFMVDEELKVWLIEVNGAPACAQKLYAELCQGIVDIAISSVFPPPDVEQPQTQPAAFIKL
  
Inhibitor
Name:
BDBM36557
Synonyms:
3-Formyltyrosine
Type:
Small organic molecule
Emp. Form.:
C10H11NO4
Mol. Mass.:
209.1986
SMILES:
NC(Cc1ccc(O)c(C=O)c1)C(O)=O
Structure:
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