Reaction Details Report a problem with these data
Target
Procathepsin L [114-333,T223A]
Ligand
BDBM36814
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
5.5±0
Temperature
298.15±0 K
IC50
>10000±0.0 nM
Citation
 Bogyo, M; Verhelst, S; Bellingard-Dubouchaud, V; Toba, S; Greenbaum, D Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. Chem Biol 7:27-38 (2000) [PubMed]  Article 
Target
Name:
Procathepsin L [114-333,T223A]
Synonyms:
CATL1_HUMAN | CTSL | CTSL1 | Cathepsin L
Type:
Cysteine Protease
Mol. Mass.:
24128.88
Organism:
Homo sapiens (Human)
Description:
P07711[114-333,T223A]
Residue:
220
Sequence:
APRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDAGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM36814
Synonyms:
MB-074
Type:
Small organic molecule
Emp. Form.:
C21H29N3O7
Mol. Mass.:
435.4709
SMILES:
CCC(C)[C@H](NC(=O)C1OC1NCCc1ccc(O)cc1)C(=O)N1OCC[C@@H]1C(O)=O |r|
Structure:
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