Affinity DataKi: 1.07E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 2.50E+3nMAssay Description:Inhibition of beta tryptaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.90E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
Affinity DataKi: 4.03E+3nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
Affinity DataKi: 6.20E+3nMAssay Description:Inhibition of beta tryptaseMore data for this Ligand-Target Pair
Affinity DataKi: 7.90E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+4nMAssay Description:Inhibition of beta tryptaseMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of plasminMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 6.5nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
Affinity DataIC50: 8.10nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 8.60nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
TargetLegumain(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 11.5nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
Affinity DataIC50: 11.5nMpH: 5.8 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
Affinity DataIC50: 15nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
TargetCaspase-3(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 130nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMpH: 7.4 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
Affinity DataIC50: 141nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
TargetLegumain(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 145nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
Affinity DataIC50: 148nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 167nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 186nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 198nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMpH: 8.0 T: 2°CAssay Description:The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...More data for this Ligand-Target Pair
Affinity DataIC50: 267nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 638nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
Affinity DataIC50: 704nMpH: 5.8 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
TargetLegumain(Homo sapiens (Human))
The Board of Trustees of The Leland Stanford Junior University
US Patent
The Board of Trustees of The Leland Stanford Junior University
US Patent
Affinity DataIC50: 704nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
Affinity DataIC50: 780nMpH: 6.25 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
Affinity DataIC50: 780nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
Affinity DataIC50: 860nMpH: 8.0 T: 2°CAssay Description:The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...More data for this Ligand-Target Pair